Prolongation of myocardial viability by proteasome inhibition during hypothermic organ preservation
نویسندگان
چکیده
منابع مشابه
Proteasome inhibition during myocardial infarction.
The ubiquitin-proteasome system (UPS) plays a central role in protein degradation and regulates a variety of critical cellular processes. During recent years, the cardiac UPS has become increasingly recognized as a key regulator of cardiac function under both physiological and pathological conditions. Numerous studies have demonstrated that altered UPS function is involved in the pathogenesis o...
متن کاملMyocardial Preservation during Hypothermic Cardiopulmonary Bypass: A Team Endeavor
____________ _ Myocardial failure is the primary cause of death following operation using hypothermic cardiopulmonary bypass. The mean mortality rate for coronary bypass in Medicare patients in the United States for 1984 was 5.5%.1njury to the heart is caused by aortic cross-clamping or total circulatory arrest. The lesion of hypoxia is characterized by progressive acidosis. The severity of aci...
متن کاملSPOTLIGHT REVIEW Proteasome inhibition during myocardial infarction
The ubiquitin-proteasome system (UPS) plays a central role in protein degradation and regulates a variety of critical cellular processes. During recent years, the cardiac UPS has become increasingly recognized as a key regulator of cardiac function under both physiological and pathological conditions. Numerous studies have demonstrated that altered UPS function is involved in the pathogenesis o...
متن کاملN-Octanoyl Dopamine, a Non-Hemodyanic Dopamine Derivative, for Cell Protection during Hypothermic Organ Preservation
BACKGROUND Although donor dopamine treatment reduces the requirement for post transplantation dialysis in renal transplant recipients, implementation of dopamine in donor management is hampered by its hemodynamic side-effects. Therefore novel dopamine derivatives lacking any hemodynamic actions and yet are more efficacious in protecting tissue from cold preservation injury are warranted. We hyp...
متن کاملTension prolongation during recovery from myocardial hypoxia.
The mechanical behavior of isolated cat, rat, and dog ventricular muscle was examined during hypoxia and after reoxygenation. During hypoxia, an early abbreviation of tension duration was followed by a decline in the rate of tension development. After reoxygenation, a marked, early prolongation of tension development and relaxation time was invariably observed with little, if any, increase in p...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2010
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.09.093